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Only qui-nidine, an isomer of quinine, has been reported more often as a cause of isolated thrombocytopenia (), but reports of quinidine-induced thrombocytopenia are now uncommon, as it is used much less often for treatment of cardiac arrhythmias.

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However the destruction of (cinchona) trees to obtain quinine made them rare and so a way of making it synthetically was sought.

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