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The proportions of subjects with any adverse event, any grade 1 or 2 adverse event, or any serious adverse event were lower in the combination-therapy group than in the isoniazid-only group.

Our results indicate that the combination-therapy regimen can be used effectively in such settings.

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Owing to the generalized nature of her presentation, she was treated with monthly ROM therapy for 5 months to which she responded well with complete clearance of lesions without experiencing any side effects.

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People with latent TB do not spread the disease.

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Since the rate of indeterminate results was very low, we did not discuss these consequences.

PAS has very low effectiveness, is poorly tolerated, and is expensive, which mean it is the last-choice drug among the second-line group.

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Synonymous variants of inefficiently translated native (wild type, WT) genes were redesigned in the head or tail or both using the 6AA, 31-codon folding optimized (31C-FO) or 31-codon folding deoptimized (31C-FD) methods.

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Identifying Hotspots of Multidrug-Resistant Tuberculosis Transmission Using Spatial and Molecular Genetic Data.

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In this respect, it is critical to be vigilant for potential risk factors that may increase the likelihood of a patient experiencing adverse hepatic events, namely the choice of the drug (see above) and patient factors.

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However, the authors used statistical methods for meta-analysis other than the currently recommended bivariate random-effects models ().

Patients at risk are mainly those with previous experience of hepatotoxic reaction to antibiotics, the aged or those with impaired hepatic function in the absence of close monitoring, making it important to carefully balance potential risks with expected benefits in primary care.

Other reasons for decreased efficacy are intestinal malabsorption (vomiting and diarrhoea) and drug interactions.

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According to Caprisa 003 (SAPiT) Study the mortality in patients who were started on Anti-retorvirals during TB treatment was 56% lower than those started after TB treatment was completed.

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Relative mRNA expression (untreated control is set as 1) levels are plotted versus concentrations of rifampicin.

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