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Wit FW, Wood R, Horban A, Beniowski M, Schmidt RE, Gray G, Lazzarin A, Lafeuillade A, Paes D, Carlier H, van Weert L, de Vries C, van Leeuwen R, Lange JM: Prednisolone does not prevent hypersensitivity reactions in antiretroviral drug regimens containing abacavir with or without nevirapine.

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Efavirenz is an HIV-1 specific, non-nucleoside, reverse transcriptase inhibitor (NNRTI).

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Ngaimisi E, Mugusi S, Minzi O, Sasi P, Riedel KD, Suda A, Ueda N, Janabi M, Mugusi F, Haefeli WE, et al: Effect of Rifampicin and CYP2B6 Genotype on Long-Term Efavirenz Autoinduction and Plasma Exposure in HIV Patients With or Without Tuberculosis.

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Genotypes of the SNP are not significantly associated with neurotoxicity syndromes (sleep disorders, hallucinations and cognitive effects) when treated with EFV-containing ART.

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In the event that any of these side effects do occur, they may require medical attention.

Despite emergence of second-generation NNRTIs and new classes of antiretroviral agents such as integrase inhibitors and CCR5 inhibitors, EFV retains his role as the preferred NNRTI for the initial antiretroviral therapy worldwide based on the regimen feasibility and cost considerations.

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The amount of filtered bicarbonate decreases until a new threshold is established and all filtered bicarbonate is then again reabsorbed, resulting in a persistent metabolic acidosis.

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