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Which is better pantoprazole or rabeprazole? Rabeprazole, which has the highest pKa of all PPIs and is therefore least stable at neutral pH, is more rapidly converted to inhibit the proton pump as compared to omeprazole, lansoprazole or pantoprazole. In older parietal cells, rabeprazole can be as much as 10 times more potent that other proton pump inhibitors.
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