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My MD suggests every two years is standard practice, and I would like another opinion on this as I don't want them this often.
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Rechallenge with mercaptopurine usually results in recurrence of the injury (within days to weeks) and should be avoided.
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Anecdotal experience suggests that adding an alternative treatment (PE, IVIg, azathioprine, cyclophosphamide, or cyclosporine A) should be considered in patients who develop adverse effects, relapse repeatedly following reduction of the prednisone dosage, or require more than 35 mg of prednisone every other day.
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After 2 years of taking it I was experiencing sweats, joint muscle pain, very dark urine, jaundiced eyes, weakness, HGB 90, abdominal pain and I decided as a last resort I would quit taking it.
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For Ulcerative Colitis "Imuran seemed to help for a few months but after prolonged use it weakened my immune system too much.
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