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What medications can cause elevated liver enzymes? What medications can cause increased liver enzyme tests (AST and ALT) levels? aspirin, acetaminophen (Tylenol and others), ibuprofen (Advil, Motrin), naproxen (Naprosyn, Naprelan, Anaprox, Aleve), diclofenac (Voltaren, Cataflam, Voltaren-XR), and. phenylbutazone (Butazolidine)

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