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Phototherapy and melatonin, two interventions that manipulate the circadian system, are being used widely for seasonal affective disorder, jet lag and some forms of insomnia.
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PubMed was searched by two reviewers (AQ and EFO) using the terms “Melatonin” and “Sleep Disorder”.
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Gynecomastia (increased breast size) has been reported in men, as well as decreased sperm count (both which resolved with the cessation of melatonin).
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